Mr. Deity
Just ran across this fairly funny religious parody: Mr. Deity. Four episodes currently available on their web site, with promises of more to come. I think self-produced sitcoms with potentially wide influence are a perfect example of why Time Magazine decided that the Person of the Year is You.
Episode 1: Mr. Deity and the Evil
There are other irreverent sitcoms and parodies on YouTube that get honorable mention, including God, Inc., Phone Call to God, and Submissive Jesus (now a real product!)
